ALT SPL MUT DB

Alternative Splicing Mutation Database

Bechtel J M, Rajesh P, Ilikchyan I, Deng Y, Mishra P K, Wang Q, Wu X, Afonin K, Grose W E, Wang Y, Khuder S, and Fedorov A
NOTE: This is the final 1.0 release of the ASMD. All substitution mutations now have a note describing the codon change involved, based on the exon phase according to the EID. Entry 11 was found to describe a substitution in the last position of its exon (so, in a splicing junction) and had to be removed. A deposition form will be forthcoming.
NOTE: Later releases of the ASMD are now available by following this link. It has a much improved interface, many more entries, a true relational database back-end, and a public deposition form. This site is preserved for now, but may disappear in the future. The link to the more permanent home for the 1.0 release is http://mco321125.meduohio.edu/~jbechtel/asmd/1.0/. Please update any bookmarks to reflect the new location.

Formula for calculating splicing effect: SE = (Fm - Fw) / (Fm + Fw)
Fm = Frequency of mutant mRNA isoform
Fw = Frequency of same isoform with wildtype exon
Download ASMD sequence database (FASTA format)
Download ASMD info file (references, notes, etc.)
Official site (additional materials, source code, etc.)
Unofficial site (temporary location of online database)
NOTE: Gene info, including exon number, is taken from the Exon-Intron Database (EID). This exon number may not agree with that in the references.
warning See paper: Shepelev V., Fedorov A. Advances in the Exon-Intron Database (EID). Briefings in Bioinformatics 2006, 7: 178-185. (PDF 111KB)


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# /Exon/   /EID ID (gene info)/   /NCBI acc. num/   /References/   /Notes/   SE
<wildtype exon sequence>
<exon sequence with mutation>